We’ve reached Week 15 of the 2025 NFL season, and while some teams aim to make late-season pushes into the postseason, others are keeping one eye on the upcoming NFL Draft and the other on their roster to see which players should and shouldn’t return. Making things more complicated at this stage of the year is injuries, and there are quite a few notable ones for bettors to know for Week 15. Here’s a breakdown of the most important injuries of Week 15, as well as what NFL betting lines look like per the latest DraftKings Sportsbook odds. We will update this post with inactives lists for every team prior to kickoff. All times Eastern.
Ravens at Bengals (1 p.m. ET)
Star Cincinnati receiver Tee Higgins is out this week with his second concussion of 2025, both of which have occurred over the last month. The Ravens need a win to try and keep pace with Pittsburgh for the division lead after dropping two games in a row to fall to 6-7.
The Ravens are 2.5-point favorites, while the total is very high at 51.5.
Raiders at Eagles (1 p.m. ET)
Kenny Pickett will be under center for the Raiders against his old team,as the former first-round pick will start in place of the injured Geno Smith, who’s dealing with shoulder and back injuries. The Eagles will again be without star tackle Lane Johnson, which is bad news against Maxx Crosby.
Vegas is a 12.5-point underdog here, with the total at just 38.5.
Cardinals at Texans (1 p.m. ET)
Marvin Harrison Jr. headlines another lengthy injury list for the Cardinals, who have lost five in a row and are just 3-10 on the year. The Texans are on the opposite end of the spectrum, having won five in a row, but they are without veteran running back Nick Chubb against a lackluster Arizona defense.
Houston is a 9.5-point favorite, and the total sits at 42.5.
Chargers at Chiefs (1 p.m. ET)
The Chargers aren’t the only AFC West team with issues on the offensive line, as two Kansas City starters are…
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