Cowboys vs. Lions prediction, odds, start time: 2025 NFL Thursday Night Football game picks by proven model

Teams battling for a playoff spot meet when the Dallas Cowboys face the Detroit Lions in a key NFC matchup on ‘Thursday Night Football.’ Dallas is coming off a 31-28 win over the Kansas City Chiefs, while Detroit dropped a 31-24 decision to the Green Bay Packers on Thanksgiving Day. The Cowboys (6-5-1), who have won three in a row, are just 1.5 games behind Philadelphia for the NFC East lead. The Lions (7-5), who have lost three of five, have fallen two games behind Chicago in the NFC North. Lions receiver Amon-Ra St. Brown (ankle) did not practice on Monday or Tuesday. 

Kickoff from Ford Field in Detroit is set for 8:15 p.m. ET. The Cowboys lead the all-time series 19-13, but the Lions won last year’s meeting 47-9. The Lions are 3-point favorites in the latest Cowboys vs. Lions odds, while the over/under for total points scored is 54.5 via SportsLine consensus. Before making any Cowboys vs. Lions picks, check out the NFL predictions from the SportsLine Projection Model. 

New users can target the DraftKings promo code, which offers $200 in bonus bets if your bet wins:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 14 on a 49-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Cowboys vs. Lions. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Lions vs. Cowboys:

Cowboys vs. Lions spread

Detroit -3 at DraftKings Sportsbook

Cowboys vs. Lions over/under

54.5 points

Cowboys vs. Lions …

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