Chiefs vs. Seahawks odds, prediction: Free expert picks for NFL preseason Week 2

The Seattle Seahawks will host the Kansas City Chiefs in the second week of the NFL preseason on Friday. The Seahawks ended their 2024 campaign 10-7 and returned to the gridiron last week with a 23-23 tie against the Las Vegas Raiders. The Chiefs went 15-2 en route to their third straight Super Bowl berth last season, but didn’t play any of their starters in their 20-17 preseason loss to the Arizona Cardinals last week.

Kickoff from Lumen Field in Seattle is set for 10 p.m. ET. Seattle is a 3-point favorite in the latest Seahawks vs. Chiefs odds, while the over/under for total points scored is 38.5 in the NFL odds. Before locking in any Chiefs vs. Seahawks picks or predictions, you need to see what proven SportsLine’s Larry Hartstein has to say. New users at bet365 can get $150 in bonus bets instantly with the latest bet365 bonus code for Friday’s game:

Hartstein is 967-821 all-time on NFL sides and props (plus 13.8 units) at SportsLine including 593-518 ATS, and cashed all five of his 2024 NFL futures plays (plus 5.35 units). 

Here are Larry Hartstein’s best bets for Seahawks vs. Chiefs on Friday:

Seahawks -3 (-105)Over 38.5 (-105) 

Seahawks -3 (-105)

The line has changed over the course of the week, going from favoring the Chiefs against the spread to swinging in the complete opposite direction. Regardless, the expert is giving Seattle the advantage here since Mike Macdonald will have Sam Darnold and some of his starters going and Andy Reid will play Gardner Minshew, Bailey Zappe and Chris Oladokun under center instead of Patrick Mahomes.

“Mike Macdonald learned under preseason legend John Harbaugh in Baltimore,” Hartstein said. “He has coached four preseason games with Seattle (2-1-1 SU) and the worst result was a 1-point loss at Tennessee last season. Play the home dog.”

Place this bet at -105 at DraftKings Sportsbook, where you can get over $200 off NFL Sunday Ticket plus get $200 in bonus bets…

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