‘Monday Night Football’ prediction, odds, time: 49ers vs. Colts picks from Niners expert who’s 18-4

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night Football. San Francisco is coming off a 37-24 win over the Tennessee Titans on Sunday, while Indianapolis dropped an 18-16 decision at Seattle. The 49ers (10-4), who are third in the NFC West, are 6-2 on the road this year. The Colts (8-6), who are third in the AFC South, are 6-1 on their home field. Indianapolis will start 44-year-old Philip Rivers for a second week in a row.

Kickoff from Lucas Oil Stadium in Indianapolis is set for 8:15 p.m. ET. The Colts lead the all-time series 27-19, including wins in each of the last five meetings. San Francisco is a 4.5-point favorite in the latest 49ers vs. Colts odds, while the over/under for total points scored is 46 at DraftKings Sportsbook. Before making any Colts vs. 49ers picks, make sure to check out the ‘Monday Night Football’ predictions from SportsLine NFL expert Micah Roberts.

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Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos’ book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. Most importantly, Roberts has a read on the pulse of the 49ers. He is 18-4 (+1360) on his last 22 against-the-spread picks in games involving San Francisco. Anyone following could have seen huge returns. 

Now, Roberts has set his sights on 49ers vs. Colts and just locked in his picks and predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines for Colts vs. 49ers: 

49ers vs. Colts spread

San Francisco -4.5 at DraftKings Sportsbook

49ers vs. Colts …

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