2025 college football picks, Week 2 odds, lines, best bets by Vegas expert: This parlay could return +600

The Week 2 college football schedule begins on Friday with four games, and continues into a Saturday full of mostly intriguing non-conference matchups. Perhaps the biggest is a top-20 showdown between Michigan and Oklahoma that features big-name quarterbacks. Five-star freshman Bryce Underwood gets his first big test for the Wolverines, while highly-touted transfer John Mateer leads the Sooners. This will be just the second-ever meeting between the programs, with OU winning in their 1976 Orange Bowl matchup.

The latest Week 2 college football odds list the Sooners as 5.5-point favorites at home. Other Week 2 college football lines of note include Ole Miss (-9.5) vs. Kentucky, Iowa vs. Iowa State (-3.5), NC State vs. Virginia (+3) and Illinois vs. Duke (+2.5). Before locking in any Week 2 college football picks, be sure to see the top Week 2 college football expert picks, predictions and best bets from Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been sports betting — and winning — for more than 30 years. After going 3-2 so far this season, he’s on a 16-8 roll in his SportsLine best bets column that dates back to last season. Anybody who followed him could have been way up.

Now, he has turned his attention to the Week 2 college football odds and is sharing his top betting picks. If you parlay these college football betting picks, you could be looking at a return of around +600. Get his top college football picks at SportsLine, and new users can also target the DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

Top Week 2 college football expert predictions

One of Casale’s top Week 2 college football picks: He is backing Kansas State (-17.5) to cover against…

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