The NFL preseason is in the books, and now all the focus turns to the Week 1 NFL schedule. It’s another strong opening slate that begins with Cowboys vs. Eagles in the 2025 NFL Kickoff Game on Thursday, Sept. 4, followed by Chiefs vs. Chargers in Brazil on Friday. Thirteen games are on the Sunday schedule, with Vikings vs. Bears wrapping it up on Monday. NFL bettors are often targeting spreads, totals and money-line NFL picks. Some key Week 1 NFL odds include the Eagles at -7.5 against the Cowboys, which has moved a half point since the Micah Parsons trade, and the Steelers at -2.5 against the Jets. The Bills, meanwhile, are -1 against the Ravens in a Sunday Night Football showdown between AFC contenders.
A set of exact Week 1 NFL score predictions can give you the tools needed to make a variety of picks for every game, as well as a guide for some NFL props you could target as well. Hitting on an exact NFL score prediction could also result in a huge payday. Before making any Week 1 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.
A SportsLine expert and host, Cohen is evaluating the entire Week 1 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight up NFL picks (69%) and was profitable for bettors. Anyone who followed Cohen’s NFL predictions has been profitable at their favorite sports betting sites and betting apps.
You can only see Cohen’s Week 1 NFL exact score predictions at SportsLine. Also, can also target the DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
Top Week 1 NFL picks
After diving into all 16 games from the NFL’s Week 1, Cohen likes the Bills (-1, 50.5) to narrowly win a rematch of their AFC Divisional Playoff Game victory over the Ravens in a 26-23 final. “In my opinion, these are the two best teams in the NFL and…
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