2025 NFL season: 100 things to know with Week 1 kickoff approaching; key games, stories, odds, predictions

Some of the biggest events of the 2025 NFL offseason are officially in the rear view. And now, with free agency, the draft and the schedule release in the books, actual football is on the way. All 32 teams have organized team activities (OTAs) and mandatory minicamps this spring, and before long, summer training camps will kick off, leading directly into the fall calendar, which is jam-packed with juicy matchups.

The reigning Super Bowl champion Philadelphia Eagles may still be basking in their Super Bowl LIX rout of the Kansas City Chiefs, especially after their signature Tush Push play was upheld during heated NFL owners meetings. Yet soon the rest of the league will be ready to challenge the crown. For Tuesday marks 100 days out from the start of the 2025 campaign on Sept. 4, when the Eagles are set to open the new schedule in prime time against the rival Dallas Cowboys.

In honor of the fast-approaching season, here are 100 things to know, including key facts and figures, early predictions and oddsmakers’ top picks for the next Super Bowl champion:

Key facts and figures

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1. The 2025 NFL season will be the 106th in league history.

2. The opening game will pit the Eagles against the Cowboys on Thursday, Sept. 4, in Philadelphia, with kickoff scheduled for 8:20 p.m. ET on NBC.

3. One day after the opener, the Chiefs will play the rival Los Angeles Chargers at Corinthians Arena in São Paulo, Brazil. It marks the NFL’s second annual South American showcase in Week 1.

4. The Chargers-Chiefs Brazil game will be exclusively streamed on YouTube, a first for the NFL.

5. The schedule will include six other international games, which are as follows:

6. Minnesota Vikings at Pittsburgh Steelers (Week 4, Sept. 28, in Dublin, Ireland)

7. Vikings at…

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