The last time the Denver Broncos made the NFL playoff bracket, they went on to win the Super Bowl. The Broncos will open the 2025 NFL playoffs with a road tilt against the Buffalo Bills, who have won five of the last seven meetings against Denver. A rookie quarterback has won a playoff game in each of the past two seasons, but should you back Bo Nix and the Broncos with your NFL Wild Card Weekend picks? According to the latest NFL Wild Card Weekend odds, Denver is an 8.5-point underdog on the road, while the over-under for total points scored is 47.5. The Texans and Ravens both advanced in the NFL playoff bracket with wins on Saturday.
The other remaining Wild Card Weekend NFL spreads include Packers vs. Eagles (-4.5, 45.5), Commanders vs. Buccaneers (-3, 50.5) and Vikings vs. Rams (+2.5, 48) from State Farm Stadium in Glendale, Arizona. Making NFL Wild Card Weekend score predictions can help form not only NFL spread picks, but also NFL over-under picks and NFL parlays. Which NFL Wild Card Weekend games will be lopsided, and which ones will play out closer to their NFL betting odds? Before you make any NFL Wild Card Weekend picks, make sure you see what SportsLine’s advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2025 NFL playoffs on an incredible 31-14 betting hot streak on top-rated NFL picks this year — a stunning 69% success rate. Longer term, it is on a 211-142 roll on top-rated NFL picks that dates back to the 2017 season and a 65-35 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps has…
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