The No. 6 seed Penn State Nittany Lions will try to maintain their impressive start to the College Football Playoff when they face the No. 7 seed Notre Dame Fighting Irish in the 2025 Orange Bowl on Thursday night, with the winner advancing to the national championship game. Penn State has cruised to victories over SMU and Boise State, winning those games by a combined final score of 69-24. Notre Dame closed the regular season on a 10-game winning streak, and it has added victories over Indiana and Georgia in the CFP. The Fighting Irish have two fewer days to prepare for this game after the Sugar Bowl was postponed from New Year’s Day to Jan. 2.
Kickoff is set for 7:30 p.m. ET on Thursday at Hard Rock Stadium in Miami. Notre Dame is favored by 1.5 points in the latest Penn State vs. Notre Dame odds, while the over/under is 46.5 points, per SportsLine consensus. Notre Dame is the -126 favorite (risk $126 to win $100) on the money line. Before locking in any Notre Dame vs. Penn State picks, you’ll want to see the college football predictions from the model at SportsLine.
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it went 43-35 on all top-rated picks this season while also nailing all four first-round College Football Playoff winners. Anyone following at sportsbooks and on betting apps has seen impressive returns.
The model has set its sights on Penn State vs. Notre Dame. You can head to SportsLine to see its picks. Here are several college football betting lines for the Notre Dame vs. Penn State game:
Notre Dame vs. Penn State spread: Notre Dame -1.5Notre Dame vs. Penn State over/under: 46.5 pointsNotre Dame…..
