Self-learning AI makes NFL against the spread, over-under, money-line picks for every Week 18, 2025 matchup

The final week of the regular season is upon us and Week 18 culminates with a head-to-head battle between the Detroit Lions and Minnesota Vikings with the NFC North and the No. 1 seed in the NFC playoff bracket on the line. The Lions are three-point favorites in the latest Week 18 NFL odds. Meanwhile, there is one playoff spot available in both conferences, with the Broncos (-10.5), Dolphins (-1), and Bengals (-1.5) vying for the AFC opening and the Buccaneers and Falcons in contention for the NFC South title.  

Who should you back in those games with playoff implications and how should you handle all your NFL money line, NFL over-under and NFL against the spread spread picks? Before you make any Week 18 NFL picks and Week 18 NFL score predictions, you need to see the NFL against the spread, NFL over-under, and NFL money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has hit a whopping 2,131 4.5- and 5-star prop picks since the start of last season.

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