College football odds, lines, schedule for Week 4: USC, Tennessee open as road favorites against ranked foes

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A chaotic start to the college football season has set the pieces in place for a midseason stretch unlike any other. With nonconference games cycling off the schedule, we begin the week-to-week grind with an eye on league play in expanded conferences with rapidly shifting landscapes. 

The Week 4 schedule is filled with enticing matchups across the country, with some of those new rivalries taking center stage. Saturday will be highlighted by three games between top-20 teams who are facing each other for the first time as conference foes. No. 11 USC squares off with No. 18 Michigan in the Big House, No. 12 Utah heads to Stillwater to play No. 14 Oklahoma State in its first-ever Big 12 road game and No. 6 Tennessee will be the first SEC visitor to No. 15 Oklahoma as Vols’ coach Josh Huepel faces the program where he won a national title as a player. 

Week 4 lines are out, so let’s take a look at what oddsmakers are thinking as well look ahead. 

Odds via SportsLine consensus 

The big games 

No. 24 Illinois at No. 22 Nebraska (-8.5) (Friday): Dylan Raiola and the Cornhuskers have looked like the team that many saw coming. Meanwhile, Illinois came from off the radar to crash the top 25 with a 3-0 start that includes a nonconference win against Kansas. Playing in Lincoln has been a tremendous home field advantage for Nebraska so far and the oddsmakers think it will be again, giving Matt Rhule’s group a two-score edge on the points spread. 

No. 11 USC (-6.5) at No. 18 Michigan: This spread, maybe more than any other in Week 4, shows two teams who have gone in opposite…

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