USC vs. LSU prediction, odds, spread, start time: 2024 college football picks, Week 1 bets by advanced model

Twenty-one years after they split a national championship, LSU and USC will finally meet on the field on Sunday evening. In 2003, LSU won the BCS Championship but USC topped the AP Poll, leading to the last split national championship in college football. The programs haven’t met since then, and this will be just the third all-time matchup between two of the biggest brands in college football. They split the prior two, with the last being an LSU victory in 1984.

Kickoff from Allegiant Stadium in Las Vegas is scheduled for 7:30 p.m. ET. The Tigers are favored by 4.5 points in the latest USC vs. LSU odds via SportsLine consensus, while the over/under for total points is 64.5. Before making any LSU vs. USC picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

Now, the model has set its sights on USC Trojans vs. LSU Tigers and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Here are the college football odds and betting lines for LSU vs. USC:

USC vs. LSU spread: LSU -4.5USC vs. LSU over/under: 64.5 pointsUSC vs. LSU money line: LSU -186, USC +155USC: The Trojans are 2-8 against the spread over their last 10 gamesLSU: The Over went 12-1 for the Tigers last season, with the best Over percentage (92.3%) in FBSUSC vs. LSU picks: See picks at SportsLine

Why LSU can cover

While LSU has the No. 9 incoming…

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