Notre Dame vs. Louisville game: Prediction, expert picks, kickoff time, live stream, how to watch, TV channel

No. 10 Notre Dame is no stranger to prime-time spotlight games this season and that trend continues in Week 6 as the Fighting Irish face No. 25 Louisville to continue their impressive run of clashes against ranked opponents. The Cardinals caught the eye of AP Top 25 voters after jumping out to their first 5-0 start since 2013, which already marks a successful beginning to the Jeff Brohm era in Louisville. Saturday night’s showdown will surely be a measuring stick for the team and the program as a whole. 

The Fighting Irish should be accustomed to centerstage after hosting Ohio State at home in a narrow loss and then defeating a ranked Duke team in a narrow win. With USC coming up next week, this matchup is just another in a series of games that will define the 2023 season. 

Louisville has gotten plenty of airtime with Friday night games against Georgia Tech and NC State, but this will be the first glimpse of the Cardinals for a good chunk of the country. Those stakes should make for a terrific atmosphere in L&N Stadium on Saturday night, with the question being whether the home crowd can play a role in the outcome of this ranked-on-ranked battle. 

Notre Dame vs. Louisville: Need to know

Notre Dame has dominated ACC opponents: The Fighting Irish began a football scheduling agreement with the ACC in 2014 and have held the upper hand for much of that relationship. Notre Dame is 42-7 against ACC opponents since the scheduling agreement began, including a run of 30 consecutive wins in regular season games against ACC foes  since the start of the 2017 season. Louisville has to avoid the familiar narrative associated with this winning streak, which is getting bullied by a dominant Notre Dame team in the trenches and falling short in key moments…

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