NFL Week 5 odds, expert picks, best bets, teasers, spreads, survivor picks, how to watch, streaming, more

Week 5 of the 2023 NFL season is here, and there are plenty of intriguing matchups to look forward to. The Jacksonville Jaguars remained abroad for their second straight London game, where they will play host to the Buffalo Bills, Nathaniel Hackett and Sean Payton come face to face when the New York Jets travel to Denver to play the Broncos, and then on Sunday night, we get what is probably the game of the week when the Dallas Cowboys take on the San Francisco 49ers.

As we do every week, we’ve collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Ready? Let’s jump in.

All NFL odds via SportsLine consensus odds.

Which picks can you make with confidence in Week 5? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up well over $7,000 for $100 players on top-rated NFL picks since its inception.

Jacksonville Jaguars at Buffalo Bills (London)

Time: Sunday, 9:30 p.m. ET (NFL Network), stream on fubo (try for free)
Open: Bills -3.5, O/U 47.5

Featured Game | Buffalo Bills vs. Jacksonville Jaguars

Katie Mox has TWO best bets for you on this matchup. She likes Bills -5.5, but also has a player prop to consider: Trevor Lawrence Under 1.5 passing touchdowns.

“Through four weeks, he’s only had four passing…

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